L-cysteine is an amino acid that contains sulfur. It can be formed in the body from methionine,which is also a sulfur-containing amino acid. Because cysteine can be easily oxidized into cystine, the stable form of L-cysteine, N-acetylcysteine (NAC), is preferred for nutritional supplements.
NAC is also the originator of glutathione, which is a combination of the three amino acids cysteine, glycine, and glutamic acid. A combination of three amino acids is referred to as a “tripeptide”.
Areas of Application
L-cysteine for hair growth
Cysteine is a fundamental ingredient in the synthesis of collagen. Collagen, in turn, is the most important element for the production of keratin in hair. Collagen is also required for supporting healthy skin and nails.
A study conducted with women suffering from diffuse hair loss found that taking cysteine in combination with millet seed extract and pantothenic acid can lead to a normalization in hair growth after just three months of therapy. 1
Cysteine for cell integrity and quality of semen
General studies have been conducted to determine the effects of glutathione on the immune system and aging processes. More recently, additional studies have focused on glutathione’s effect on sperm development in men. These studies have shown that taking glutathione can significantly improve sperm development. 2 A study involving male students under exam stress showed that stress contributes to low glutathione levels in semen and low quality of sperm. 3
In cases of cough, NAC is generally recommended at a dose of 600 mg per day as a medication to dissolve mucus. Please pay close attention to dosage recommendations of medications.
For long-term therapy, a dose of 50 mg – 100 mg L-cysteine is recommended. The amino acid is available in the form of a safe nutritional supplement.
In the form of N-acetylcysteine (NAC), cysteine stimulates production of secretions and thereby dissolves mucus. To relieve coughing, it is primarily used as an expectorant. When using an expectorant, be sure not to take a cough suppressant.
L-cysteine is well tolerated when taken in the long-term dosages indicated above and even in doses over 500 mg.
- W. Gehring, M. Gloor; Das Phototrichogramm als Verfahren zur Beurteilung haarwachstumfördernder Präparate am Beispiel einer Kombination von Hirsefruchtextrakt, L-Cystin und Calciumpanthotenat; Zeitschrift für Hautkrankheiten, 2000; 75(7/8):419-423 (The phototrichogram process as evaluaiton of hair growth stimulating compounds using as an example the combination of millet fruit extract, L-cystine, and calcium pantothenate; Magazie for Skin Diseases) ↩
- Lenzi A, Culasso F, Gandini L, et al. Placebo-controlled, double blind, cross-over trial of glutathione therapy in male infertility. Hum Reprod 1993; 8:1657-1662 ↩
- Eskiocak S., Gozen A.S., Yapar S.B., et al.; “Glutathion- und freie Sulfhydrylkonzentration im Samenplasma gesunder Medizinstudenten während und nach Pruefungsstress”; Hum Reprod 2005; 20(9):2295-600 (Glutathione and free sulfhydryl concentrations in semen plasma in healthy medical students during and after exam stress”) ↩